My wife and I are planning to try for our second child towards the end of this year. I am on the cusp of getting Allopurinol prescribed. Should I wait until we do conceive to start the drug? Are there any known affects of conceiving while on this drug? Birth defects? Even infertility? Any help would be appreciated!
Allopurinol, Colchicine and other drugs Cause Male Infertility
I raised this question to my doctor and he informed me the infertility issues with Allopurinol are more for females, not males. Is this accurate? I want to make sure. Any insight would be helpful. Thanks.
To clarify, Sigman analyzes 5 measurements of male infertility, including Decreased Libido, Erectile Dysfunction, and Fertilization Potential. For both allopurinol and colchicine, the only adverse event recorded was Fertilization Potential.
Also, the report specifically mentions colchicine:
Colchicine has been reported to induce oligospermia; however, this was demonstrated in a study of patients with Behçet’s disease with long-term exposure. Short-term use in healthy males induced no effect on semen parameters and it is unclear if spermatogenic defects are due to the long-term use or underlying disease.
Finally, the citations for the colchicine facts are:
Sarica K, Suzer O, Gurler A, Baltaci S, Ozdiler E, Dincel C. Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur Urol. 1995;27:39–42.
Haimov-Kochman R, Ben-Chetrit E. The effect of colchicine treatment on sperm production and function: a review. Hum Reprod. 1998;13:360–362.