Colchicine + Z- Pack = BAD??? HELP

Gout Support Home Page Forums Please Help My Gout! Gout Treatment Colchicine + Z- Pack = BAD??? HELP

This topic contains 21 replies, has 7 voices, and was last updated by Avatar of KeithTaylor KeithTaylor 1 year, 4 months ago.

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  • #3001
    Avatar of cjeezy
    cjeezy
    Participant

    I started a prescribed Z-pack yesterday for a bout of bronchitis I'm trying to get over.  Well unfortunately I hd some twinges this morning so  I took 2 colchicine when I woke up and then another 1 every hour for the next 4 hours or so.  Long story short is I got really dizzy, couldn't think straight, had trouble breathing and felt the worst I've ever felt in my life. I'm sure anxiety symptoms were there too.  I called the pharmacist and she said that those to drugs shouldn't be mixed and for me to stop theColchicine immediately?  WTF? I had to leave work to lay down.  I havent taken Colchicine in over 4 hrs now and feel a little better. but I know the drug could have delayed effects.  How long until this stuff is outta me.  This is awful, plus I still have gout pain.  I left a message with my Dr, but havent heard back yet.

    #5804
    Avatar of trev
    trev
    Participant

    Colchicine is not a drug to mess with- in my  exp. when co- admiinistered with other drugs.

    My last adventure on this was with statins and it took a couple of days for my system to reset, and that was on 6 x 0.5 mg Colch. over a day.

    The only antibiotic I usually take is incompatible with Colch also. (Erythromicin]

    I did feel pretty weird and the fact that medics don't actualy have much, if any,personal experience of what side effects can come about, makes it worse!

    If you're still at work, I would consider a few days rest to get your system steady-Likewise, any exercise regime.

    We're not  machines- and drugs , apart from the pain and worry about the illness, take toll on our metabolism at the best of times- which we don't always allow for.

    #5808
    Avatar of zip2play
    zip2play
    Participant

    I have read that the MOST severe drug interaction might be had with clarithromycin and colchicine. Clarithromycin like erythromycin AND azithromycin (Z-pak) are all macrolide antibiotics and interfere with the liver's ability to break down other drugs.

    (Hint: they also prevent the breakdown of Cialis…with the most pleasant of consequences.Cool)

    Coincidentally all three are contraindicated with statins and I had a DOOZY of a reaction between Lipitor and clarithromycin after ear surgery…leg pain so bad I bent down to get something and wound up on the floor unable to muster the strength in my legs to get up. Scared the Schitte out of me. I can get away with the Z-pak and even erythromycin but I will NEVER take clarithromycin again.

    Remember cjeezy, Azithromycin has an EXTREMELY long half life…that's why you need take only 3 (or 6 of the older variety.) So be sure to wait til several days AFTER your last pill before taking another colchine. Yes, you are caught between a rock and a hard place…maybe give Aleve a try.

    #5814
    Avatar of cjeezy
    cjeezy
    Participant

    That was probably one of the worst days Ive had in a very long time! Dr never called me back yesterday.  This morning they left me a message saying to stop taking the Z pack and that they called me in another antibiotic called Keflex (or something like that).  Any ideas? How long does Colchicine stay in my system?  This is probably the worst situation for me now.  I cant breath and my foot is getting worse!

    #5817
    Avatar of zip2play
    zip2play
    Participant

    Keflex is a cephaloprin, so probably alright. Colchicine stays in the system for DAYS, just like azithromycin.

    The upside, if there is one, is that the Z-pak is preventing the breakdown of the colchicine thus you are getting the the benefit of a much larger dose…good and bad.

    How many of each did you take? Do you have the 6 X 250 Z-pack or the 3 x 500.

    #5819
    Avatar of cjeezy
    cjeezy
    Participant

    Hi Zip,

    I took 6 or 7 .6mg Colchicine’s and 2 250mg of the Z pack the night b4. It just really pisses me off that the Dr didn’t see that the 2 could have a bad interaction. Luckily the 400mg of Alleve I took today is helping to somewhat keep my gout pain at bay. I started 300mg of AP today too. Next week Ill post me UA levels. Ill tell u, in the past month I have felt just horrible. I hope all this passes soon!

    #5821
    Avatar of Utubelite
    Utubelite
    Participant

    Hi cjeezy,

    I hope you should be out of this drug interaction mode soon.

    I have couple of friends who have Gout experience and they rely on Aleeve. They actually talk so high about Aleeve and have never taken a Colchicine( one of them heard this name from me for the first time).

    I have no experience but Aleeve may workout as an alternative to Colchicine and help you till you can resume Colchicine. 

    #5826
    Avatar of zip2play
    zip2play
    Participant

    Okay cjeezy get ready for a doozy factoid: the half life of azithromycin is 68 HOURS. The half life of colchicine once it gets into the white blood cells can be 60 HOURS.

    It is a good thing that you took only 500 mg zithromax.

    I hope you aren't taking a statin too.

    Thank you for doing the Aleve experiment. I love the drug and am AMAZED it's OTC but have never used it for gout pain. Maybe if cochicne prices go to infinity, it will become my mainstay.

    #5827
    Avatar of cjeezy
    cjeezy
    Participant

    No statins for me…luckily. I guess it will be a while b4 I can start Colchicine again. Should I have any worries about these two drugs still interacting in my system? I feel much better today, but as you said (also my pharmacist) these drugs have an extremely long half life.

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