How Fast Does Colchicine Work?

About GoutPal’s Old Gout Forum Forums Please Help My Gout! How Fast Does Colchicine Work?

This topic contains 35 replies, has 8 voices, and was last updated by  KeithTaylor 1 year, 6 months ago.

Viewing 18 posts - 19 through 36 (of 36 total)
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  • #11147

    trev
    Participant

    bflat..  Don't wear the 'don't need an SUA test' bit.  Get one after 2 weeks…

    Round attack time, it is a flaky reading, true-

    but you need to monitor SUA to diagnose and treat gout effectively. GP Rule #1 🙂

    PS: As to novels, some people put too little [very common]- and some too much data here posting.

    Better to have more info than not -and getting it off the chest can be very theraputic, as many here would attest!

    #11152

    Newbflat
    Participant

    Thanks all for your encouragement.

     

    So 7 .6 mg pills  of colchicine down in 28 hours. The runs have set in so I'm stopping for now. The toe is better but still a little sore on the side and the tendon on top hurts if i try and rase my big toe up.

    Im a little concerned as there was a little mucousy blood in my stool so I'm stopping.  I still have 2 days of Prednisone left so I'm hoping  the flare will fade now.

    Im concerned with colchicine toxicity now.  While Im only having minor stomach issues with the drug. Im curious if anyone else has had issues with a small amount of blood in there stool, Is this common?

    Thinking about starting Allopurinol soon and I'm wondering since i only have 300mg pills if i should start off with 300mg or quarter them  and start slow… like 75mg for 2 days, then 150 for two, then 225 for 2….. ect?

    Bill…

    #11155

    trev
    Participant

    Bill, never ignore blood in stools- it may be a dodgy colon [common in over 50 y.o] and the Colchicine could aggravate this. Report this event to Doc before you do another course.

    On the AP- some start  a week @ 100mg to check reactions before upping to 200 or 300 -which is the useful dose.

    In two weeks use you will probably tell compatibilty OK- though after a few weeks, I felt a bit weird and came off them, going onto Sulfinpyrazone instead.

    #11160

    zip2play
    Participant

    Newb,

     

    Stopping the colchicine at the onset of diarrhea is the way to go. You took a full dose and you should need no more. If the blood continues, think about a colonoscopy in the future…always a good idea if you are over 50. Although I wouldn't think blood in stool is common, the viciousness of the diarrhea  seems likely to cause bleeding with hemmorhoids, diverticulitus or a host of other common conditions

    Today is the day after…how do you feel? Did the cure work?

     

    Start with the 300 mg allopurinol. The full dose will cause fewer attacks than a small dosage. There's a good possibility that the 300 mg. dose will see the end of your attacks.

     

    Good Luck.

    #11164

    MyFootHurts
    Participant

    Colchicine price is up at the local CVS pharmacy.

     

    I went in today to fill my monthly allopurinol and colchicine prescriptions.  CVS charges $12 for 30 generic pills.

     

    Last month 30 colchicine cost $16.  Today they wanted $26.

     

    I told them no thanks.

     

    I have 500+ colchicine pills from India vacuum packed in the freezer.  I'm not going to pay CVS their price.

    #11166

    Newbflat
    Participant

    My foot was nearly pain free the next morning. The best its been in 3 weeks (the stuff works!). Still A little soreness in the tendon if i try to rase my big toe and still a hint of swelling. The blood stopped the moment i stopped taking the colchicine. Gut feels like it recovering from something it didn't like.

    I was essentially pain free until  9pm and started to have tingles and pricks on the side of my big toe/ foot joint.  In a minor panic i dipped into my stash on prednisone and took 3 pills.  This worked threw the night and i took three more in the morning.

    My foot has been about as well as it was yesterday morning and as on now at 11pm still feels good. I think i will do three prednisone tomorrow and then three days at 2 and three at 1…

    I will talk to my doc tomorrow about the blood and see what he says.

    Im nervous about taking Allopurinol now as im really enjoying being pain free for the first time in a while. Im also traveling to Mexico for two weeks and wondering what my best approach might be in not having pain while I'm there..

    1. Start taking Allopurinol now and see if i get any pain and treat as it comes.

    2. Start taking Allo and 1-2 colchicine as a prophylaxis (assuming its ok with the Doc and my bowls) at least threw all the time I'm there?

    3. Don't take anything and deal with flare ups if they come.

    4.  Prophylaxis Colchicine and nothing else….. treat any flare ups NSAID's or predisone.

    So many options……. I realize there is no right answer.

    All this has me concerned. I have never taking so many drugs in such a short time….. It has me worried..

     

    Ps.. My girlfriend now refers to my toe as ” Your Majesty” ….as it rules my life and is a royal pain!

    #11169

    zip2play
    Participant

    You have 2 right answers and one better than the other:

     

    Best:

    2. Start taking Allo and 1-2 colchicine as a prophylaxis (assuming its ok with the Doc and my bowls) at least threw all the time I'm there?

    Good:

    1. Start taking Allopurinol now and see if i get any pain and treat as it comes.

     

    But make sure you take 300 mg. allopurinol and not 100 mg.

     

    Ps.. My girlfriend now refers to my toe as ” Your Majesty” ….as it rules my life and is a royal pain!

    I guess they don't call gout the “disease of kings” for nothing.

     

    WOW, MFH,

    Five hundred colchicine…I thought my 150 was a hoarde. (Come Armegeddon, I guess gouties will come banging on our doors…with pitchforks and crutches.)

    PS. I have 10 year old colchicine that was stored at room temperature that is still completely fresh…than God.

    What was your average cost per pill? Mine was about $.15, all bought at U.S. pharmacies before the Colcrys-FDA ripoff.

    #11170

    MyFootHurts
    Participant

    When I last got colchicine from India, I paid $152.07 USD, including shipping, for 440 x 0.5mg

    That works out to $0.415 USD per 0.6 mg.

    I simply cannot afford $5 per pill for Colcrys, so now I have stockpiled enough colchicine to last a long time.  I'm glad to hear it has a ten year shelf life.

    #11183

    Newbflat
    Participant

    Quick update

    I'm on 2 pills of prednisone for the next 2 days and then one for three days.  At the moment Im totally pain free and it feels soooo.. good.

    I spoke to the Doc and had my blood drawn today. Doc says the blood in the stool sounded ok as described as there was not any in the stool itself just on the surface and it stopped as soon as i stopped the colchicine.  We are waiting on the blood test results  on Thursday or friday.

    Assuming everything is ok with my kidneys and liver i will go on 2 Colchicine a day and Allopurnol keeping an eye on my bowls.  Then in a month down to one colchicine and stay there for ….?  Treat flare ups with NSAID's or prednisone.

    Im anxious to hear what my UA level is.

    I was talking to a security guard were i work and he told me he has been on 300mg allopurinol and 2 colchicine a day for…. 27 years. His last attack was 5 years ago.

    #9646

    Newbflat
    Participant

    UA levels from the doc didn't arive yet but i did get my UASure test kit in the mail today…. very fast indeed.

    First off.. i read all the threads i could find about using the meter and tried my best to be consistent and use enough blood

    This is what i did

    I have use the control solution to check the meter and it is within the 3.4-5 range specified. One control test at 3.6 and one at 4.7.

    The first blood test i applied a good sized drop to the edge of the strip as shown in the instructions and left a good bit on top as well. . All 4 times it immediately filled the strip to the triangular end and beeped.

     blood tests the readings were 5.7 mg/DL, 10.9, and 7.4. and an hour  later 5.6

    This does not leave me with much confidence in the tester.

    I sent an email to the company and asked for a better description of how to get consistent readings.

     

    Toe is feeling very good at the moment. Hopfuly my UA, Liver and kidneys test will be in tomarow.

    #9645

    trev
    Participant

    Yes Bill- the readings do seem too random for comfort.

    I use the Kernel meter and my beef with that one is that the date gains slowly over time and this makes me wonder -if they can't get that right , how accurate is the other bit? [2 meters- the same fault]

    However, on accuracy I got better readings than yours except going high when sample site not dry enough or I spat on the strip edge to get it to beep 🙂 . That DID read high…

    Are you allowing the alcohol prep to evapaorate off well first?

    Seeing your report it looks like you have taken pretty good care to get a good reading- so don't give up just yet, it takes  a while to get 'in the swing' and even then, a spurious reading can be expected time to time.

    The main thing is to get an average 'working level' SUA to gauge effects of diet,lifestyle and meds. Once meds kick in you will use the meter a LOT less , most probably, as you gain control of SUA levels -which can vary up to 2 points throughout the day, anyway & remember – we're all different.

    #7105

    Newbflat
    Participant

    So i finally got my blood results back.

    This test was 4 days after 7 colchicine
     and after 3 weeks on prednisone with a week+ to go……..

    Kidney function was good.

    Liver function had slightly a elevated level in one enzyme (ALT(GPT)  76  

    My UA level was 6.9 mg/DL

    I have been testing my UA in the mornings before breakfast.

    2/25….6.7
    2/26… 5.5
    2/27….7.4
    1/28….6.8

    At the moment i have no foot pain at all. Im off prednisone today but possibly too fast as I'm having some BAD headaches. There easily stopped with ibuprofen. I have read this is common with being on prednisone for this long. Im also coming down with a bad case of acne, its all over my forehead, back and shoulders. I read this is common as well with prednisone with long term usage…. Im glad to be done with it.

    Im taking one colchicine tonight and i guess one starting tomorrow morning. I haven't started to take Allopurinol yet as i was waiting for my tests to come back.   

    It looks from my official test and my home testing i seem to to be walking the line of 6.8. I haven't eaten any meat in the last month nor have i had a drink.  But i have been eating a lot of beans, both black and pinto. This makes me wonder if my “normal” UA level was something like 7.9 before being on a more gout friendly diet…?

    One thing that most likely didn't help… I use to eat a LOT of brewers yeast. Mostly on popcorn. I would put a big handful on a big bowl of popcorn and eat the whole thing. I did this 3+ times a week. And always before any evening i thought i might be drinking a lot. Its a major B12 hit and a very good hangover prophylaxis…. Considering how much i use to eat im suprised i didn't come down with gout sooner.

    I guess i will start taking Allopurinol tomorrow (didn't talk to the Doc, just a letter with blood test results and a message on my voice mail) and test my levels in a month to check my UA and liver enzymes.
    I will just dive in i guess and start taking 300mg and see what happens. What should i expect and what should i watch out for diving i like this. What does an allergic reaction look like vs. getting use to it?

    I just can't decide if i should take colchicine as a prophylaxis or just take it as needed when I'm having an attack.

    Decisions , decisions…

    #7672

    zip2play
    Participant

    I just can't decide if i should take colchicine as a prophylaxis or just take it as needed when I'm having an attack.

     

    I would take it prophylacticlaly for a week, maybe 2 each morning and then stop. But if next month you wake up with any twinges, take two and if discomfort isn't relieved then one more in an hour and maybe one more after that. But probably the first two will turn the trick.

    You can use this technique for the rest of your life…the secret is to do it FAST, as soon as you feel the bugeoning of an attack. The longer you wait the more colchicine is required.

    #11213

    Newbflat
    Participant

    Update

    I have been taking Allopurinol  for 6 days now and i think i can see it beginning to work.. I am also taking one .6mg colchicine in the morning with the Allo.. and one in the evening.  I feel my foot tingle just a touch in the morning before i take my Colchicine and it does as well in the evening just before taking my evening dose. This morning and evening tingling started with Allopurinol. I really feel like taking Colchicine as a prophylaxis is keeping an attack at bay at the moment.

    Here are my UA home test results in total.

    Official level (lab) …6.9
     
    Home test….
    2/25…6.7
    2/26…5.5
    2/27…7.4
    2/28 ..6.8
    3/1… 6.0
    Started Allopurinol
    3/2….8.1
    3/3….7.7
    3/4….5.8
    3/5….5.4
    skipped a day
    3/7… 4.6…………. i think its working!

    Im off to Mexico in the morning for two weeks and Im not taking my test kit.
    I will pick up as much Colchicine as i can carry back!….

     

    Bill…

    #11214

    zip2play
    Participant

    Sounds good Bill.

    That's a nice allopurinol response in a short time.

    #11296

    Newbflat
    Participant

    Update..

    Im back from Mexico and remained attack free for the duration. I am on 300mg Allopurinol and at first .6mg colchicine twice a day.  When i was down there i purchased (colchicina) from the local pharmacies. It comes in 1mg pills scored down the center. So i started taking .5 mg twice a day a day  (snapped the pills in half) along with the Allopurinol.

    The Colchacina is what it says on the package (bubble pack of 10 1mg pills x 2 packs per box, 20 pills total) and in almost invisible lettering it says Colchiquim.  I was offered two different manufactures, one a brand name the other generic. I chose the generic. The cost was 25 pesos ($2.08) for a box of 20 1mg pills. ……I bought 120 img pills so it cost me about $12.50 to buy $1600 (at current US prices) worth of Colchicine.

    120 1mg pills gives me enough for 4 months at my current rate. I guess i should have bought some more but once i had a stash i sort of forgot about it.  My only question is….. is it good?  Well i don't know. I have been taking it for a little over two week now and my toe don't feel any different than when i was taking somthing that cost about $13.25 a day….  vs. $ .10 … I guess thats good!?

    I do have this feeling colchicine is keeping an attack at bay while I'm starting Allopurnol. I get tiny twinges in my toe several times a day reminding me about my gout and it does seem to happen most in the morning and evening before i take my twice daily dose of colchicine. I had one 'extra' twinge late one night that made me nervous so i took two naproxen and had no problems after that. ….. Sooooooo. I feel that the Mexi-cholchine is good, but i won't really know until i use it for an attack and it does its….. thing.

    Is my the Allopurinol working?…. i think so. I didn't take my test kit down there but since i have been back its been…

    Mar…

    22… 4.6

    23… 5.9

    24… 4.6

    25… 5.4

    26… 5.3

    That averages to 5.1 since i have been back.

    My plan is to take 2x .5mg colchicine a day with Allopurinol (forever)… for three months and then .5mg colchicine at night for a month to test the water. If ok after a month i will stop the colchicine. I will treat any twinges with naproxen and reserve the colchicine for emergences…. at least thats the plan!

    Im really beginning to feel a sence of having got this under controle and an enormance sence of relief. . I realise there might be battles ahead and i will need to be ever vigilant. But what i have learned here has given me the tools to manage my gout and the tools know what to do if i have an attack….. I thank all my 'pals' here for all there help and i thank the inventors of the internet, without whom we would all be in a lot more pain!

     

    Bill in Seattle.

    #11300

    zip2play
    Participant

    It sounds like you are doing fine. I'm glad your trip to Mexico wasn't kebolluxed by an attack.

     

    Perhaps your plan for all that colchicne is overkill but you will find out and adjust accordingly.

     

    It feel good to have a big pile of colchicine in your closet doesn't it? (Ay carumba senor, mucha colchicina…ole'!)

    #14564

    KeithTaylor
    Participant

    This indomethacin topic is now closed.

    It started with asking: how long does it take for indomethacin to work? Unfortunately, this never got answered, and it turned into a general chat about colchicine.

    I will move the relevant parts of the discussion to a new common questions section, as time allows. In the meantime, you can easily search for current discussions, or start a new discussion.

    In fact, if you still want to know “how long does it take for indomethacin to work” please start a new discussion, with some information about your situation so we can help. I cannot promise that it will stay on topic, but I can give a hint about a new personal support service. When that is available, your questions will always get answered – if an answer is possible.

    You can find the search box at the top of every page, or at the foot of the right-hand sidebar. Even easier, please use the gout search page.

    Please browse the Gout Treatment guidelines for best information.

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