How Fast Does Colchicine Work? About GoutPal’s Old Gout Forum › Forums › Please Help My Gout! › How Fast Does Colchicine Work? Tagged: How long does it take for Colcrys (colchicine) to work? This topic contains 35 replies, has 8 voices, and was last updated by KeithTaylor 1 year, 10 months ago. You should log in to GoutPal to reply to this topic. If you do not want to log in, use the orange Support button, or raise a new GoutPal helpdesk ticket. Please note that I respond quicker in the gout forums, compared to the helpdesk.