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8:43 am
June 7, 2009
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zip2play
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Post edited 1:46 pm – June 7, 2009 by zip2play
Here's a thorough list of all the MAJOR, MODERATE and MINOR drug interactions with Lipitor. It's from drugs.com, a source that I find quite reliable. There are HUNDREDS mentioned but I cannot find a mention of a colchicine interaction.
http://www.drugs.com/drug-inte…..04105.html
(I would never conside cochicine an immunosuppressant…they are talking about anti-rejection drugs and that's a VERY special subcategory of people. I have a dear friend who has taken them daily for 30 years to avoid rejecting a cadaver kidney…her drug interactions are LEGION.)
If you are still concerned, remember the half life of simvastatin is only 3 hours. So if you need colchicine, just skip the simvastatin.
As an aside, if you DO take a statin, NEVER combine it with a macrolide antibiotic…I thought I was going to be crippled with leg pain when my STUPID doctor gave me an erythromycin derivative with no knowledge of it's iinteraction with Lipitor.
His reaction: “Oh GEE, I didn't KNOW that!”
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12:15 pm
June 7, 2009
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trev
Tophi Terror
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Zip:
I did post some links with covering text but it seems to have gone west!
Google 'Colchicine statins' and you'll see a few refs. including this one
http://www.theannals.com/cgi/c…../40/7/1466
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10:21 pm
June 8, 2009
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zip2play
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Gosh,
Amyloidosis and nephrotic syndrome, unable to breathe and with altered mentation (demensia) and daily colchicine for 3 YEARS…and then atorvastatin for a month. So they judged Rhabdo (which Lipitor alone can cause) and then they cured him. But he dies of pneumonia before leaving the hospital.
Really, that gave me the giggles. The man was walking dead and blaming a drug interaction seems a reach. Sounds more like DEATH BY HOSPITAL (probably more common than most people realize.) Had they given the poor guy just aspirin atop all his problems, he'd have still been a dead duck.
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2:21 am
June 9, 2009
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trev
Tophi Terror
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Maybe I picked the wrong quick reference Zip- there were others. I know you use the combo.
I did think myself that it was incredibly bad fortune for the poor fellow.
However it does raise the point about such interactions and like all thesedrug side effect questions can raise anxiety when we get to the small print- both on the drugs leaflet and sometimes in prime research issues.
It would be really good if drugs worked as expected, had no side effects and didn't end up needing more to correct damage done- but as recently said- it's not a perfect world.
Incidently I stopped the statin to restart Colch. as the galloping gout was hunting for more sites-on the way to joint3 in the ankle. {after your comment about Statin half life being 3 hours only]
I've not withheld Colch. before and I wouldn't recommend stopping midway – if nothing else, pain thresholds don't improve second time around :( - and as we know 'G' don't take many prisoners!
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9:02 am
June 9, 2009
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zip2play
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I know you use the combo.
I guess, in truth, ”USE THE COMBO” really doesn't pertain to me because, although I use Lipitor daily I have NEVER found a need to use colchicine more than one day. Even the worst attack of my life was stopped with 22 colchicine tabs in a single day. Perhaps now, once a month I will have a twingy warning, real or imagined, and then I will pop 2 colchicine…and then rarely 2 more an hour apart. Maybe if I took it on a daily basis I'd be more careful.
I went to the fine print of the Lipitor package insert (good to read it oncee or twice a year ) and there is no mention of an interaction with colchicine. But let me repeat something from a crippling personal experience:
Clarithromycin:
Concomitant administration of atorvastatin 80 mg with
clarithromycin (500 mg twice daily) resulted in a 4.4-fold increase in atorvastatin
AUC (see WARNINGS, Skeletal Muscle, and DOSAGE AND
ADMINISTRATION).
That AUC is area under the curve…combo of time and effective dosage. NEVER take clarithromycin and a statin or ANY macrolide antibiotic but clarithromycin is by far the the worst.
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9:20 pm
June 14, 2009
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Scotto
Toe Torture (status changes after 50 posts)
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Hi Guys
Very interesting and in depth reading. I would just like to share my results from my tester that i got in April after being on the appurinol for the last month. The results seem to be reasonably consistent.
23-4-09 0900 5.2 after breakfast 1 hour ealier
27-4-09 1000 5.0 after big week end
30-4-09 1700 4.8
4-5-09 0900 5.2 had seafood night before
5-5-09 new paket of strips and tested with solution came within range
5-5-09 2030 5.9 after dinner highest reading to date
11-5-09 1530 5.8
12-5-09 0800 3.7 before blood test by proffessional it was cold seemed unusual reading
12-5-09 0830 4.9 after blood test by proffessional as i thought the one before wasn't right probably not enough blood
my DR said the result was .39 must be in other units not sure what the conversion is
21-5-09 0830 5.7
25-5-09 0830 4.3
30-5-09 0820 5.4 thought i was having an attack as ankle has swollen and accillies is sore
10-6-09 0800 3.9
15-6-09 0900 5.3 Ankle swollen again played squash 4 days ago
The Dr gave me Colgout 0.5g and indocin 25mg to take 3 times a day for 10 days to get rid of the pain in my ankle and it seemed to clear it up straight away. Ihave been having problems with my ankle on and off seems to be no rhyme or reason to it.
Dr said my UA level was fine obviosly the allpurinol working but I have a lot of other problems with my blood test High blood sugar, High colesterol bad liver function test. I have backed right off the alchol now 4 days a week without and cut down on the other days and trying to exercise more.
All in all i think the tester is giving me a gauge that my UA is down, mornings seem to be lower than evenings.
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7:49 am
June 15, 2009
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zip2play
Member
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It looks like your readings are good but oh my, what a discrepancy between the low lab results and yours? Is is possible the lab results were always on an empty stomach and yours not so much?
One lab reading was pretty high and that was the .39 on the molar standard. Just divide this number by 0.059 to get mg/dL and it is a 6.6 mg/dL. That seems to fly in the face of your 3.7 and 4.9 before and after that professional blood draw. Presents the problem WHICH TO BELIEVE?
Your crabby ankle may be pain totally unrelated to gout and it responded to indocin or it could be tophaceous where you will need to suffer on and off until it is cleaned out.
It seems all is going pretty well and your numbers are good control. Let's just call that 6.6 at the doctor's “anomalous.”
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10:21 pm
June 15, 2009
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Scotto
Toe Torture (status changes after 50 posts)
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Thanks for that
I'll just take the colgout next time my ankle is sore and not the indocid as you said earlier in this thread. Just to prove a point (whether dodgey ankle or gout related).
I have only had the 1 lab test on the 12-6-09 which seems high (if i got the values right) in comparison to the reading the UA sure tester gave me all 3 tests are within half hour of each other and had nothing to eat. So that makes a big difference between the lad and the uasure.
I will keep testing it seems to give me where i am. Next lab test in 2 months i will let you know
Cheers
Scotto
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3:59 am
June 17, 2009
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tim
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i have been checking uric acid levels on the uasure meter and my results are generally between 5.9 and 6.5 sometimes slightly higher. am currenlty on 100mg of allapurinol a day. was wondering if anyone knows if i should get this increased. still getting some slight pain in foot every now and again.
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4:35 am
June 17, 2009
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GoutPal
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Some pain is to be expected until all uric acid crystals have been dissolved. How long you have had gout, and how long you have been taking allopurinol are major factors.
A temporary increase in dose, for a few months, might be a good idea if your medical history indicates that the pain is due to undissolved uric acid crystals. If it is due to joint erosion from years of untreated gout, then there is little you can do about it. You should see your doctor to assess if an increased dosage is likely to benefit you.
Anyone on allopurinol should be scheduled for uric acid tests. The frequency will depend on the length of time you have been taking allopurinol, and the trend of your uric acid levels from “official” test results. Unfortunately, it is not yet a criminal offense to prescribe allopurinol without follow-up blood tests and aftercare, so it is up to you to insist that you get this.
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Unless replying to specific points in this topic, please start a new topic. See new topic link above, or gout forum guidelines.
Current gout status in my profile.
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7:31 am
June 17, 2009
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zip2play
Member
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tim,
Very few gouties can get away with only 100 mg. allopurinol. You certainly will do better with 200 mg. (and then maybe 300 mg. which is the “class average.”)
Getting your number down a bit from the 5.9- 6.5 is probably a good idea and it will probably stop the now and again foot pain.
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4:56 pm
June 29, 2009
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Aviator
Toe Torture (status changes after 50 posts)
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It's been awhile since I posted, but the foot has been doing much better lately. Started Allopurinol almost exactly 30 days ago. Learning to use Colchicine as needed and it appears to work well with halting any increase in pain as that has happened a couple of times as I've used the foot more.
What I thought would be of interest is my experience with the UASure test kit. I received my kit and started monitoring about 2 weeks before starting Allopurinol and my results really give me confirmation of the drugs effects. I've seen a marked decrease in UA levels as measured by the UASure:
5/16 – 7.2
5/22 – 7.9
5/22 – 9.5
5/23 – 8.9
5/23 – 8.0
5/25 – 7.0
5/27 - 7.3
5/28 – 8.4
5/30 – 9.9 – Started 300mg Allopurinol
6/1 – 6.7
6/2 – 4.5
6/5 – 5.6
6/8 – 4.9
6/15 – 5.6
6/22 – 4.4
6/29 – 5.4
In the past 30 days since starting Allopurinol as measured with the UASure test device, my SUA levels haven't risen above 7. I've seeing marked improvement in my mobility and levels of pain. I've scheduled a visit with a Rheumatologist and will confirm my readings with another lab blood test but I think I'm on the right track.
Thanks everyone for your feedback and abundance of information on this site.
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7:02 am
June 30, 2009
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zip2play
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That's terrific Aviator.
Your readings including the first day you took allopurinol averaged 7.4.
Your last 6 readings averaged 5.1 The allopurinol sure did what it's supposed to.
I purposely ignored the June 1 reading because the major metabolite of allopurinol is oxypurinol which works for days and is thus cumulative so the first day of allopurinol isn't likely to accumulate much oxypurinol. THus the first day after you take allopurinol isn't really representative of BEFORE or AFTER…best ignored.
Thus the BEST estimate of your allopurinol is pobably the average of reading after the first WEEK of allopurinol when one would expect steady state blood level of the drug…and that gives you again an excellent 5.1 mg./dL…you seemed to find your correct dosage on the first try.
Good luck with a lifetime of allopurinol and the ability to eat whatever you want unless you want sweetbreads in an anchovie sauce washed down with a 6-pack too often.
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4:56 am
July 7, 2009
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vegetarianGuy
Tophi Terror
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Just got back from my GP and home kit reading matched GP's reading. My home kit reading was 525 and GP's was 521. So atleast I know which sized drop is accurate from now on.
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I don’t want to cut my foot off any more! Thank you LORD ALLOPURINOL (fingers crossed)
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1:28 pm
July 28, 2009
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Steve Smith
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Anyplace in the US to buy the UASure test kit?
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3:36 am
July 29, 2009
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GoutPal
Admin
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Arctic Medical ship the UASure uric acid test kit worldwide. As far as I know, there is no USA distributor.
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Unless replying to specific points in this topic, please start a new topic. See new topic link above, or gout forum guidelines.
Current gout status in my profile.
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10:34 am
July 29, 2009
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Tavery
Swollen Joints
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I got it from Artic Medical a couple months ago and I live in Seattle. It was fast and painless. No problems with exchange rates or anything.
If you do order it, get a couple boxes of test strips at the same time to save shipping costs later on. There are 25 in a box.
Also order their lancets. The lancet tool that comes with the testing unit works great and the lancets are very cheap.
I test first thing in the morning right after shower but before I eat. I usually lance my ring finger on the side of the finger near the nail instead of trying to penetrate the thicker pad. I find this heals fast and doesnt interfere with my life of typing and whatnot.
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8:56 am
February 15, 2010
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dp14
Toe Torture (status changes after 50 posts)
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I woke up Saturday morning with the 4th gout episode of my life, all in left big toe joint. Limping around all weekend in big pain. This episode is the 1st one in over 1.5 years, and the last one lasted three weeks. Started tons of fresh lemon juice/water, eating right, and no beer (my big downfall). Feeling better this morning, but still there (can walk almost normal).
I have a UASURE from about 7 months ago, but never got it working right. Followed all your posts on here and it seems to be working good now (thanks!). Main thing is make sure you insert strip in cleanly without touching anything but end, wash finger you want to use, and prick it and get a decent sized drop going and just touch it to sensor.
I have tested three times/day since saturday morning (morn, noon, night):
Sat: 5.9, 6.5, 6.7
Sun: 5.6, 6.2, 6.2
Mon: 6.7, two more later today
So some questions
1) What are good ranges to keep my gout @ bay to be in? What # do I need to be below all the time?
2) I'm 46 – in great shape, and eat resonably good. With 4 gout attacks in 4-5 years, does any recommend I see dr. and get a perscription to allpurinol – is it time to just do that all the time?
3) Last attack 1.5 years ago – I tried Colchicine for a week – it did nothing for me, is that normal?Tons of cherry concentrate juice, and fresh-squeezed lemon with water seemed to finally clear me up in week 3
Thanks all – 1st post, but have been reading these forums for quite some time.
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10:06 am
February 15, 2010
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zip2play
Member
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With 4 gout attacks in 4-5 years, does any recommend I see dr. and get a perscription to allpurinol
No, not yet.
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11:00 am
February 15, 2010
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trev
Tophi Terror
| | England | |
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The general rule of thumb seems to be stay below 6mg/dl on average to avoid situation worsening any- but lower by a point to assist UA removal- but the mechanism for this without meds is unclear.
Now many more people are using self tests and keeping notes it will help to bring new ideas up.
I think that whole body acidity level is very important to bring into the equation. It's not mentioned much by medics and apparently can cause much illness, not just contribute to gout, in those susceptible.
Blood Ph stays very constant usually, saliva can idicate an imbalance- but doesn't change that much, though being easy to measure with the same strips as for urine.
btw: 3 weeks seems the usual full length of attack[tapering off] with or without special diet measures.
'BBB' [see other posts] is really noticeable to me in its' good effects.
[1 Hour, or two to ease twinges ,anyway!]
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