Bedevilled By Uric Acid
Posted by GoutPal in Gout, tags: albumin, msu, _uric acid, _uric acid crystalsIn a recent gout forum post about uric acid, zip2play wondered why there aren’t more people with gout. Or rather, how come so many people have higher than normal uric acid, but never get gout?
This intrigued me also, as it has others, and I found “Growth of monosodium urate monohydrate crystals: effect of cartilage and synovial fluid components on in vitro growth rates.”
In this study, Burt and Dutt found that
“Albumin significantly inhibited MSUM [monosodium urate monohydrate] crystallisation.”
Their findings apparently contradict other studies, which they suggest might be due to the difficulty of studying albumin which can be absorbed by lab equipment.
It is unfortunate that this is not the subject of much more analysis. It seems to me that there are substances (probably including iron), which promote uric acid crystallization. There must be others which inhibit it.
Interestingly, albumin is found in dairy products that have been shown to have a statistical link to lower incidence of gout.
Does anyone know of any current, or more recent, research in this area? The study I refer to was published in 1986.
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