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I personally would not take more than 8 x 0.5 mg tabs a day in the first days of an attack- and be wary of long term use due to effects on white blood cells and immune suppression.
The other thing to take account of is drug /drug interactions and Statins, commonly used for high chloresterol/triglicerides is one of these such, that react badly when co-administered.
I have experienced this- but not the more serious effects possible , as I ceased quickly due to gastric effects.
Side effects are neglected/understated (for obvious reasons)- often to the detriment of the unsuspecting user.
Long term I would take only one or two a day for a month or two when initiating uric acid lowering treatment with another drug.
For an ACUTE attack that has persisted for several days I follow the dosing maximum given on my original packing slip with my first Rx: 2 to start, then one and hour to a maximum of 16, pain cessatiion, or serious diarrhea. If you start immediately upon feeling the pain 2 or 4 should do the trick. I can attest from personal experience that one does not QUITE die from taking 22 pills in a day,
but I don't recommend it.Ah, the great colchicine dosing debate. This one could run, and run…..
But seriously, the high dose regime to kill the acute attack is fine. It is NOT fine to ignore the long term, which as zip2play quite rightly says, needs uric acid lowering treatment. The only way to manage gout pain is to manage uric acid numbers.
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